Effects of endomorphin on substantia gelatinosa neurons in rat spinal cord slices
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چکیده
منابع مشابه
Actions of midazolam on GABAergic transmission in substantia gelatinosa neurons of adult rat spinal cord slices.
BACKGROUND Although intrathecal administration of midazolam has been found to produce analgesia, how midazolam exerts this effect is not understood fully at the neuronal level in the spinal cord. METHODS The effects of midazolam on either electrically evoked or spontaneous inhibitory transmission and on a response to exogenous gamma-aminobutyric acid (GABA), a GABA(A)-receptor agonist, muscim...
متن کاملBiphasic modulation by galanin of excitatory synaptic transmission in substantia gelatinosa neurons of adult rat spinal cord slices.
Although intrathecally administrated galanin modulates nociceptive transmission in a biphasic manner, this has not been fully examined previously. In the present study, the action of galanin on synaptic transmission in the substantia gelatinosa (SG) neurons of adult rat spinal cord slices was examined, using the whole cell patch-clamp technique. Galanin concentration-dependently increased the f...
متن کاملAction of dexmedetomidine on the substantia gelatinosa neurons of the rat spinal cord
Dexmedetomidine is a highly specific, potent and selective alpha(2)-adrenoceptor agonist. Although intrathecal and epidural administration of dexmedetomidine has been found to produce analgesia, whether this analgesia results from an effect on spinal cord substantia gelatinosa (SG) neurons remains unclear. Here, we investigated the effects of dexmedetomidine on postsynaptic transmission in SG n...
متن کاملAction of isoflurane on the substantia gelatinosa neurons of the adult rat spinal cord.
BACKGROUND Although isoflurane, a volatile anesthetic, can block the motor response to noxious stimulation (immobility and analgesia) and suppress autonomic responsiveness, how it exerts these effects at the neuronal level in the spinal cord is not fully understood. METHODS The effects of a clinically relevant concentration (1 rat minimum alveolar concentration [MAC]) of isoflurane on electri...
متن کاملSynaptic modulation and inward current produced by oxytocin in substantia gelatinosa neurons of adult rat spinal cord slices.
Cellular mechanisms for antinociception produced by oxytocin in the spinal dorsal horn have not yet been investigated thoroughly. We examined how oxytocin affects synaptic transmission in substantia gelatinosa neurons, which play a pivotal role in regulating nociceptive transmission, by applying the whole-cell patch-clamp technique to the substantia gelatinosa neurons of adult rat spinal cord s...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2003
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0705534